ADAM12 and ESM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ADAM12	ESM1
Description		ADAM metallopeptidase domain 12	endothelial cell specific molecule 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	Hepatocyte Growth Factor Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Positive Regulation Of Angiogenesis	Angiogenesis Sprouting Angiogenesis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Pathways		Signaling by EGFR Invadopodia formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)	Cocaine dependence ( 31212010) Familial squamous cell lung carcinoma ( 29924316) Sense of smell ( 26632684) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		42 interacting genes: ACTN2 ADAMTSL4 CYSRT1 DOCK1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D TUBGCP2 YES1	15 interacting genes: ADAM12 ANKS1A AQP1 BANP FAM124B FRS3 HDAC7 HOXA1 ITGB2 MEOX2 NRF1 NUFIP2 PRKAB2 VGLL3 YY1
Entrez ID		8038	11082
HPRD ID		04092	03310
Ensembl ID		ENSG00000148848	ENSG00000164283
Uniprot IDs		A8K6G4 O43184 U5NE98	Q9NQ30
PDB IDs
Enriched GO Terms of Interacting Partners?
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