SLC1A3 and SGK1

Number of citations of the paper that reports this interaction (PubMedID 12911626)
29

Data Source:
HPRD (in vitro)

		SLC1A3	SGK1
Description		solute carrier family 1 member 3	serum/glucocorticoid regulated kinase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Membrane Protein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Speck
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Glutamate:sodium Symporter Activity Glutamate Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Neurotransmitter Uptake Ion Transport Neurotransmitter Transport Cellular Sodium Ion Homeostasis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Light Stimulus Gamma-aminobutyric Acid Biosynthetic Process Response To Wounding L-glutamate Transmembrane Transport Cranial Nerve Development Auditory Behavior Response To Antibiotic Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance L-glutamate Import Transepithelial Transport D-aspartate Import Across Plasma Membrane Cellular Response To Cocaine Potassium Ion Transmembrane Transport L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Long-term Memory Regulation Of Blood Pressure Peptidyl-serine Phosphorylation Regulation Of Cell Migration Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A3 causes episodic ataxia 6 (EA6)	Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription
Drugs		Glutamic acid	Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases
GWAS		Depression in smokers ( 30219690) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Malaria ( 31844061) Serum alkaline phosphatase levels ( 33547301)	Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		7 interacting genes: BTN2A2 MGST3 RFX3 SGK1 TMEM120B TMEM128 ZDHHC17	37 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C UBC
Entrez ID		6507	6446
HPRD ID		02523	04264
Ensembl ID		ENSG00000079215	ENSG00000118515
Uniprot IDs		A0A024R050 A0A087WT87 A0A087X0U3 B4DF14 P43003 Q7Z5T0 Q8N169	B7Z325 E9PR89 O00141
PDB IDs		5LLM 5LLU 5LM4 5MJU	2R5T 3HDM 3HDN
Enriched GO Terms of Interacting Partners?
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