SGK1 and KCNJ1

Number of citations of the paper that reports this interaction (PubMedID 12684516)
54

Data Source:
HPRD (in vitro)

		SGK1	KCNJ1
Description		serum/glucocorticoid regulated kinase 1	potassium inwardly rectifying channel subfamily J member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Speck	Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity	Inward Rectifier Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Long-term Memory Regulation Of Blood Pressure Peptidyl-serine Phosphorylation Regulation Of Cell Migration Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Regulation Of Signal Transduction By P53 Class Mediator	Potassium Ion Transport Excretion Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription	Potassium transport channels
Drugs		Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Bethanidine Glimepiride Minoxidil Acetohexamide Tolbutamide Glymidine Yohimbine Agmatine Butamben
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		37 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C UBC	10 interacting genes: APLP2 CTSV EI24 GOLGA3 NID2 PRKCD SGK1 SH3RF1 SLC9A3R1 SLC9A3R2
Entrez ID		6446	3758
HPRD ID		04264	08981
Ensembl ID		ENSG00000118515	ENSG00000151704
Uniprot IDs		B7Z325 E9PR89 O00141	A0A024R3K6 A8K432 P48048
PDB IDs		2R5T 3HDM 3HDN
Enriched GO Terms of Interacting Partners?
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