SLC1A3 and RFX3

		SLC1A3	RFX3
Description		solute carrier family 1 member 3	regulatory factor X3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Membrane Protein Complex	Chromatin Extracellular Region Nucleus Transcription Regulator Complex
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Glutamate:sodium Symporter Activity Glutamate Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Neurotransmitter Uptake Ion Transport Neurotransmitter Transport Cellular Sodium Ion Homeostasis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Light Stimulus Gamma-aminobutyric Acid Biosynthetic Process Response To Wounding L-glutamate Transmembrane Transport Cranial Nerve Development Auditory Behavior Response To Antibiotic Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance L-glutamate Import Transepithelial Transport D-aspartate Import Across Plasma Membrane Cellular Response To Cocaine Potassium Ion Transmembrane Transport L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of Insulin Secretion Cilium Assembly Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A3 causes episodic ataxia 6 (EA6)
Drugs		Glutamic acid
Diseases
GWAS		Depression in smokers ( 30219690) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Malaria ( 31844061) Serum alkaline phosphatase levels ( 33547301)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Body mass index ( 28552196) Gout ( 25967671) Insomnia ( 29520036) Major depressive disorder ( 27479909) Monobrow thickness ( 26926045) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure in sickle cell anemia ( 24058526) Weight ( 28552196)
Interacting Genes		7 interacting genes: BTN2A2 MGST3 RFX3 SGK1 TMEM120B TMEM128 ZDHHC17	19 interacting genes: AK3 BIN1 CDK1 CREB1 EWSR1 FHL2 FHL3 IRF6 MEOX2 NANS PBRM1 PKNOX1 RFX1 RFX4 RFX6 SLC1A3 TMEM9B TRAF2 TRIP6
Entrez ID		6507	5991
HPRD ID		02523	03215
Ensembl ID		ENSG00000079215	ENSG00000080298
Uniprot IDs		A0A024R050 A0A087WT87 A0A087X0U3 B4DF14 P43003 Q7Z5T0 Q8N169	P48380
PDB IDs		5LLM 5LLU 5LM4 5MJU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?