RFX3 and AK3

		RFX3	AK3
Description		regulatory factor X3	adenylate kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Transcription Regulator Complex	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Adenylate Kinase Activity Protein Binding ATP Binding GTP Binding Nucleoside Triphosphate Adenylate Kinase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of Insulin Secretion Cilium Assembly Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development	ADP Biosynthetic Process Blood Coagulation Nucleoside Triphosphate Biosynthetic Process Phosphorylation AMP Metabolic Process GTP Metabolic Process ITP Metabolic Process UTP Metabolic Process
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Body mass index ( 28552196) Gout ( 25967671) Insomnia ( 29520036) Major depressive disorder ( 27479909) Monobrow thickness ( 26926045) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure in sickle cell anemia ( 24058526) Weight ( 28552196)	Crohn's disease ( 22412388) Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 27863252) Mean spheric corpuscular volume ( 32888494) Platelet count ( 26805783 22139419 29403010 20139978) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) White blood cell count ( 27863252)
Interacting Genes		19 interacting genes: AK3 BIN1 CDK1 CREB1 EWSR1 FHL2 FHL3 IRF6 MEOX2 NANS PBRM1 PKNOX1 RFX1 RFX4 RFX6 SLC1A3 TMEM9B TRAF2 TRIP6	8 interacting genes: APPBP2 DAPK3 FBLN1 KRTAP10-8 PUM3 RFX3 TRIM54 ZDHHC17
Entrez ID		5991	50808
HPRD ID		03215	12439
Ensembl ID		ENSG00000080298	ENSG00000147853
Uniprot IDs		P48380	Q7Z4Y4 Q9UIJ7
PDB IDs			1ZD8 6ZJB 6ZJD 6ZJE
Enriched GO Terms of Interacting Partners?
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