RFX3 and NANS

		RFX3	NANS
Description		regulatory factor X3	N-acetylneuraminate synthase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Transcription Regulator Complex	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	N-acylneuraminate Cytidylyltransferase Activity N-acylneuraminate-9-phosphate Synthase Activity N-acetylneuraminate Synthase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of Insulin Secretion Cilium Assembly Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development	CMP-N-acetylneuraminate Biosynthetic Process Carbohydrate Biosynthetic Process Glycosylation
Pathways			Sialic acid metabolism
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Body mass index ( 28552196) Gout ( 25967671) Insomnia ( 29520036) Major depressive disorder ( 27479909) Monobrow thickness ( 26926045) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure in sickle cell anemia ( 24058526) Weight ( 28552196)	Alopecia areata ( 25608926) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		19 interacting genes: AK3 BIN1 CDK1 CREB1 EWSR1 FHL2 FHL3 IRF6 MEOX2 NANS PBRM1 PKNOX1 RFX1 RFX4 RFX6 SLC1A3 TMEM9B TRAF2 TRIP6	20 interacting genes: APC AURKA BCL10 BUB1 CDH1 CTNNA1 EGFR FBXO7 FBXW7 FLCN MCC MLH3 MSH6 ODC1 PDGFRL PTPRJ RFX3 SRC STK11 TLR2
Entrez ID		5991	54187
HPRD ID		03215	07285
Ensembl ID		ENSG00000080298	ENSG00000095380
Uniprot IDs		P48380	Q9NR45
PDB IDs			1WVO
Enriched GO Terms of Interacting Partners?
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