RFX3 and RFX4

Number of citations of the paper that reports this interaction (PubMedID 11682486)
19

Data Source:
HPRD (in vitro, in vivo)

		RFX3	RFX4
Description		regulatory factor X3	regulatory factor X4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of Insulin Secretion Cilium Assembly Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development	Regulation Of Transcription By RNA Polymerase II Telencephalon Development Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Regulation Of Protein Processing
Pathways
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Body mass index ( 28552196) Gout ( 25967671) Insomnia ( 29520036) Major depressive disorder ( 27479909) Monobrow thickness ( 26926045) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure in sickle cell anemia ( 24058526) Weight ( 28552196)	Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cognitive test performance ( 17903297) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart rate ( 23583979) Morning person ( 30696823) Night sleep phenotypes ( 27126917) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triglyceride levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: AK3 BIN1 CDK1 CREB1 EWSR1 FHL2 FHL3 IRF6 MEOX2 NANS PBRM1 PKNOX1 RFX1 RFX4 RFX6 SLC1A3 TMEM9B TRAF2 TRIP6	3 interacting genes: ESR1 RFX2 RFX3
Entrez ID		5991	5992
HPRD ID		03215	04905
Ensembl ID		ENSG00000080298	ENSG00000111783
Uniprot IDs		P48380	Q33E94
PDB IDs
Enriched GO Terms of Interacting Partners?
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