FBXL17 and SUFU

  • Number of citations of the paper that reports this interaction (PubMedID 31560077)
  • 2
  • Data Source:
  • BioGRID (enzymatic study)

FBXL17

SUFU

Description F-box and leucine rich repeat protein 17 SUFU negative regulator of hedgehog signaling
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adult body size ( 32376654)
  • Bipolar disorder (body mass index interaction) ( 24322204)
  • Body mass index ( 25673413 28448500)
  • Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
  • Body mass index in physically active individuals ( 28448500)
  • Carotid intima media thickness x smoking interaction ( 32117412)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Estimated glomerular filtration rate ( 31015462)
  • Experiencing mood swings ( 29500382)
  • Eye color ( 23118974)
  • General factor of neuroticism ( 30867560)
  • Hand grip strength ( 29691431)
  • Intelligence (MTAG) ( 29326435)
  • Intraocular pressure ( 29235454)
  • Irritable mood ( 29500382)
  • Mean corpuscular volume ( 32888494)
  • Metabolite levels ( 23823483)
  • Moderate-to-late spontaneous preterm birth ( 31194736)
  • Neurociticism ( 29500382)
  • Number of children ever born ( 27798627)
  • Pulse pressure ( 30224653)
  • Response to amphetamines ( 22952603)
  • smoking initiation in schizophrenia ( 33691233)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Weight ( 28552196)
  • Adult body size ( 32376654)
  • Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359)
  • Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359)
  • Allergy ( 27182965)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Body mass index ( 25673413 28448500)
  • Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
  • Body mass index in physically active individuals ( 28448500)
  • Body shape index ( 34021172)
  • Brain morphology (MOSTest) ( 32665545)
  • Creatinine levels ( 29403010)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Eosinophil counts ( 32888494)
  • Estimated glomerular filtration rate ( 30604766)
  • Glomerular filtration rate ( 29403010)
  • Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
  • Height ( 28552196)
  • Hip circumference adjusted for BMI ( 34021172)
  • Nickel levels ( 26025379)
  • Optic disc size ( 31809533)
  • Platelet count ( 32888494)
  • Prostate cancer ( 23535732)
  • Refractive error ( 32231278)
  • Sum eosinophil basophil counts ( 27863252)
  • Systolic blood pressure ( 30578418)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for body mass index ( 34021172 25673412)
  • Waist-to-hip ratio adjusted for BMI ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
  • White blood cell count ( 29403010)
Interacting Genes 39 interacting genes: ACSBG2 AK9 C21orf91 CCSER1 CFAP58 CLPX COG2 ETFA FILIP1L HADH IDO1 IFT46 KBTBD8 KEAP1 KLHL12 KLHL7 MED14 METAP2 OLR1 PCCB PHF7 PPP3CB PRMT1 PSME4 PXYLP1 RLF SCG5 SCPEP1 SRBD1 SUFU TASP1 TGFBI TMEM126A TMOD1 TPP2 UAP1 USP25 ZMYM2 ZNF350 51 interacting genes: ABI3 AKR1C1 BFSP2 BTRC CRTC2 CRX DISC1 EDA2R FBXL17 FXR1 GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 ITCH KRT27 KRT75 L3MBTL3 LAMTOR3 LCA5 LGALS3 LZTS1 MAGEL2 MEOX2 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 SH3RF1 SLC41A3 STK36 STX19 TLE5 ZIC1 ZNF114 ZNF219 ZNF263 ZNF330 ZNF446 ZNF763 ZNF764 ZSCAN18
Entrez ID 64839 51684
HPRD ID 10950 06124
Ensembl ID ENSG00000145743 ENSG00000107882
Uniprot IDs Q9UF56 A0A223LX15 Q9UMX1
PDB IDs 6W66 6WCQ 1M1L 4BL8 4BL9 4BLA 4BLB 4BLD 4KM8 4KM9 4KMD 4KMH
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?