FBXL17 and KEAP1

  • Number of citations of the paper that reports this interaction (PubMedID 32814905)
  • 3

FBXL17

KEAP1

Description F-box and leucine rich repeat protein 17 kelch like ECH associated protein 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adult body size ( 32376654)
  • Bipolar disorder (body mass index interaction) ( 24322204)
  • Body mass index ( 25673413 28448500)
  • Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
  • Body mass index in physically active individuals ( 28448500)
  • Carotid intima media thickness x smoking interaction ( 32117412)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Estimated glomerular filtration rate ( 31015462)
  • Experiencing mood swings ( 29500382)
  • Eye color ( 23118974)
  • General factor of neuroticism ( 30867560)
  • Hand grip strength ( 29691431)
  • Intelligence (MTAG) ( 29326435)
  • Intraocular pressure ( 29235454)
  • Irritable mood ( 29500382)
  • Mean corpuscular volume ( 32888494)
  • Metabolite levels ( 23823483)
  • Moderate-to-late spontaneous preterm birth ( 31194736)
  • Neurociticism ( 29500382)
  • Number of children ever born ( 27798627)
  • Pulse pressure ( 30224653)
  • Response to amphetamines ( 22952603)
  • smoking initiation in schizophrenia ( 33691233)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Weight ( 28552196)
  • Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483)
  • Body mass index and systolic blood pressure (bivariate analysis) ( 33539483)
  • Body mass index and waist-hip ratio (pleiotropy) ( 29868124)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Crohn's disease ( 28067908)
  • Inflammatory bowel disease ( 28067908)
Interacting Genes 39 interacting genes: ACSBG2 AK9 C21orf91 CCSER1 CFAP58 CLPX COG2 ETFA FILIP1L HADH IDO1 IFT46 KBTBD8 KEAP1 KLHL12 KLHL7 MED14 METAP2 OLR1 PCCB PHF7 PPP3CB PRMT1 PSME4 PXYLP1 RLF SCG5 SCPEP1 SRBD1 SUFU TASP1 TGFBI TMEM126A TMOD1 TPP2 UAP1 USP25 ZMYM2 ZNF350 96 interacting genes: ADH5 AK4 AMER1 ANKS1A ARPC1B ASTN1 ATG5 BAD BNIP3L BPTF C2orf68 CARD10 CARM1 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DPP3 EAF1 EGFR ERBIN ERICH5 ETF1 FAM117B FBXL17 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL2 KLHL3 KPNA6 LAMC1 LAMTOR5 LONP1 LSM3 MAD2L1 MAPKBP1 MCM3 MCMBP MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PALB2 PANX1 PAQR4 PDCD6IP PPP1R13L PRKAG1 PTMA RAF1 RECK RELA RTN4R S1PR2 SDC1 SENP1 SLC5A5 SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRIM15 UBC UBE2D1 USP15 VAC14 WDR83 WHRN ZNF121 ZNF177 ZNF266 ZSCAN32
Entrez ID 64839 9817
HPRD ID 10950 12079
Ensembl ID ENSG00000145743 ENSG00000079999
Uniprot IDs Q9UF56 A0A024R7C0 Q14145
PDB IDs 6W66 6WCQ 1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A
Enriched GO Terms of Interacting Partners?
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