PTBP2 and PKN2

		PTBP2	PKN2
Description		polypyrimidine tract binding protein 2	protein kinase N2
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GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding MRNA Binding	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Small GTPase Binding Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding Protein Serine Kinase Activity
	Biological Process	MRNA Processing RNA Splicing Negative Regulation Of RNA Splicing Regulation Of RNA Splicing	Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Peptidyl-serine Phosphorylation Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility
Pathways			RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Daytime nap ( 33568662) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 19571811 22688191) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398 30944420) Waist circumference ( 25673412)	Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 31562340) Intraocular pressure ( 29617998) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Narcolepsy ( 23459209) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Periodontal microbiota ( 22699663) Photic sneeze reflex ( 27182965) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Rosacea symptom severity ( 29771307) Serum protein levels (sST2) ( 23999434) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure ( 30224653 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		22 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GBP1 GOLGA2 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 OGT PCBP3 PKN2 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA TOM1	19 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTBP2 PTPN13 RHOA SUMO2
Entrez ID		58155	5586
HPRD ID		12233	03972
Ensembl ID		ENSG00000117569	ENSG00000065243
Uniprot IDs		A0A6Q8PFE6 A0A7I2RVZ4 B4DSS8 B4DSU5 Q9UKA9	Q16513
PDB IDs		2CQ1 2MJU 4CQ1	4CRS 4RRV 6CCY 6GBE
Enriched GO Terms of Interacting Partners?
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