PKN2 and MYO9B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		PKN2	MYO9B
Description		protein kinase N2	myosin IXB
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Actin Filament Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Small GTPase Binding Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding Protein Serine Kinase Activity	Microfilament Motor Activity Actin Binding GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding Small GTPase Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Roundabout Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Peptidyl-serine Phosphorylation Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility	Rho Protein Signal Transduction Actin Filament-based Movement ARF Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	Regulation of actin dynamics for phagocytic cup formation RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle FCGR3A-mediated phagocytosis
Drugs		Fostamatinib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 31562340) Intraocular pressure ( 29617998) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Narcolepsy ( 23459209) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Periodontal microbiota ( 22699663) Photic sneeze reflex ( 27182965) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Rosacea symptom severity ( 29771307) Serum protein levels (sST2) ( 23999434) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure ( 30224653 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Asthma ( 32296059) Body shape index ( 34021172) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 27841878) Glycated hemoglobin levels ( 24647736 34059833 28898252) Height ( 20881960 31562340 29782485) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Prostate cancer (early onset) ( 29892016) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Selective IgA deficiency ( 27723758) Spleen volume ( 34128465) Systolic blood pressure ( 27841878 30578418) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172)
Interacting Genes		19 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTBP2 PTPN13 RHOA SUMO2	7 interacting genes: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2 RAB8A
Entrez ID		5586	4650
HPRD ID		03972	03677
Ensembl ID		ENSG00000065243	ENSG00000099331
Uniprot IDs		Q16513	B0I1T6 Q13459 Q4LE74 Q8WVD2
PDB IDs		4CRS 4RRV 6CCY 6GBE	5C5S 5HPY
Enriched GO Terms of Interacting Partners?
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