PKN2 and NCK2

  • Number of citations of the paper that reports this interaction (PubMedID 10026169)
  • 23
  • Data Source:
  • HPRD (in vitro)

PKN2

NCK2

Description protein kinase N2 NCK adaptor protein 2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Age at first sexual intercourse ( 34211149)
  • Alanine aminotransferase levels ( 33547301 34315874)
  • Aspartate aminotransferase levels ( 33547301 34315874)
  • Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)
  • Coronary artery disease ( 29212778)
  • Diastolic blood pressure ( 27841878)
  • General risk tolerance (MTAG) ( 30643258)
  • Heel bone mineral density ( 30598549 28869591)
  • Height ( 20881960 25282103 31562340)
  • Intraocular pressure ( 29617998)
  • Liver enzyme levels (alanine transaminase) ( 33972514)
  • Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757)
  • Narcolepsy ( 23459209)
  • Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095)
  • Paclitaxel disposition in epithelial ovarian cancer ( 29367611)
  • Periodontal microbiota ( 22699663)
  • Photic sneeze reflex ( 27182965)
  • Pulse pressure ( 27841878)
  • Red blood cell count ( 32888494)
  • Refractive error ( 32231278)
  • Response to fenofibrate (LDL cholesterol levels) ( 27002377)
  • Rosacea symptom severity ( 29771307)
  • Serum protein levels (sST2) ( 23999434)
  • Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
  • Systolic blood pressure ( 30224653 27841878)
  • Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
  • Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
  • Waist circumference adjusted for body mass index ( 34021172)
  • White matter hyperintensity volume ( 33293549)
  • White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
  • Addiction ( 23533358)
  • Alzheimer's disease or family history of Alzheimer's disease ( 33589840)
  • Anti-chlamydia trachomatis IgG seropositivity ( 33204752)
  • Mean platelet volume ( 32888494)
  • Platelet distribution width ( 32888494 27863252)
  • Systolic blood pressure in sickle cell anemia ( 24058526)
Interacting Genes 19 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTBP2 PTPN13 RHOA SUMO2 171 interacting genes: ABI1 ABI2 ABI3 ANKRD55 ANKS1B ARHGAP32 ATN1 AXIN1 AXL BCAR1 BCL11A BTG1 C4orf17 CBARP CBLB CCDC120 CCDC33 CD3E CHN1 CHN2 CIB1 CIPC CLEC17A CPSF6 CPSF7 CUEDC1 DDR1 DEFB124 DISC1 DLGAP4 DNM1 DOCK1 DOK1 DRAP1 DTX3 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EFS EGFR EIF3H ERBB2 ERBB3 ERBB4 FAM124A FAM47A FAM53C FAM83A FASLG FBXL19 FCRL2 FGFR1 FOSB FXR2 FYB1 GAB1 GAREM1 GGN HNRNPK HOMEZ HOXA1 HOXC4 HOXD8 HSF2BP ILK INCA1 INTS2 IRS1 KCTD17 KHDRBS1 KIAA0408 KIAA1217 KIT KLHL24 KLHL35 KPRP LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MBD6 MEOX2 MET MIA3 MNT MYPOP NCKIPSD NELFA NET1 NFKBID NHSL2 NPAS2 NPHS1 NR5A1 NTRK2 NUTM2F ONECUT3 PAK1 PAK2 PBX4 PDGFRB PHETA1 PIK3AP1 PKD1 PKN2 PRDM6 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMD10 PTK2 RASSF7 RBBP8NL RBM26 REEP4 REL SCML2 SCX SF1 SF3A2 SF3B4 SHD SKAP2 SMARCB1 SNW1 SOCS7 SORBS2 SOS1 SPATA2L SPATC1L SPRY2 SRMS SRPK1 SRPK2 SSH3 SYNGAP1 SYNPO TCF4 TCP10L TMEM121 TNR TRIM27 TRIM41 TRIP6 TXK UBC USP32 VARS2 VPS37B WAS WASF1 WASL WBP11 WIPF1 WIPF2 ZBTB12 ZBTB42 ZBTB7B ZC2HC1A ZC2HC1B ZNF341 ZNF526 ZNF688
Entrez ID 5586 8440
HPRD ID 03972 05378
Ensembl ID ENSG00000065243 ENSG00000071051
Uniprot IDs Q16513 A0A0S2Z4M6 E7ERP6 O43639
PDB IDs 4CRS 4RRV 6CCY 6GBE 1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?
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