GJD2 and PAK6

		GJD2	PAK6
Description		gap junction protein delta 2	p21 (RAC1) activated kinase 6
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GO Annotations	Cellular Component	Plasma Membrane Connexin Complex Integral Component Of Membrane	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Cell Junction
	Molecular Function	Gap Junction Channel Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Cell-cell Signaling Transmembrane Transport	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension
Pathways		Electric Transmission Across Gap Junctions Gap junction assembly	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Axial length ( 25823570 24144296) Congenital left-sided heart lesions ( 25138779) High myopia ( 31816047 32428537) Hyperopia ( 25233373) Myopia ( 27182965 25233373) Refractive error ( 23396134 32231278 20835239) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		3 interacting genes: LNX1 LNX2 PAK6	28 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1
Entrez ID		57369	56924
HPRD ID		09521	06426
Ensembl ID		ENSG00000159248	ENSG00000137843
Uniprot IDs		A0A654IE23 Q9UKL4	A0A024R9Q4 Q9NQU5
PDB IDs		2N6A	2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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