TREM2 and UNC5B

Number of citations of the paper that reports this interaction (PubMedID 27477018)
227

Data Source:
BioGRID (pull down)

		TREM2	UNC5B
Description		triggering receptor expressed on myeloid cells 2	unc-5 netrin receptor B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Plasma Membrane Raft	Plasma Membrane Integral Component Of Membrane Membrane Raft
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Phosphatidylethanolamine Binding Kinase Activator Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Signaling Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding Lipoteichoic Acid Binding Lipoprotein Particle Binding Scaffold Protein Binding Sulfatide Binding Protein Tyrosine Kinase Binding	Netrin Receptor Activity Protein Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Microglial Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of Inflammatory Response To Antigenic Stimulus Response To Ischemia Phagocytosis, Recognition Phagocytosis, Engulfment Humoral Immune Response Memory Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Lipid Metabolic Process Osteoclast Differentiation Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Detection Of Lipopolysaccharide Detection Of Peptidoglycan Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 6 Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Glial Cell Apoptotic Process Social Behavior CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Regulation Of Innate Immune Response Positive Regulation Of Osteoclast Differentiation Respiratory Burst After Phagocytosis Positive Regulation Of Complement Activation, Classical Pathway Astrocyte Activation Response To Axon Injury Positive Regulation Of Protein Secretion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Activation Positive Regulation Of Chemotaxis Lipid Homeostasis Regulation Of Resting Membrane Potential Positive Regulation Of Phagocytosis, Engulfment Microglial Cell Proliferation Negative Regulation Of Astrocyte Activation Pyroptosis Negative Regulation Of Fat Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Glucose Stimulus Cellular Response To Lipid Cellular Response To Hypoxia Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Dendritic Cell Differentiation Dendritic Spine Maintenance Import Into Cell Regulation Of Hippocampal Neuron Apoptotic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Complement-mediated Synapse Pruning Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Amyloid-beta Clearance By Cellular Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Inward Rectifier Potassium Channel Activity Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of P38MAPK Cascade Positive Regulation Of Microglial Cell Activation Negative Regulation Of Autophagic Cell Death Positive Regulation Of Microglial Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Low-density Lipoprotein Particle Clearance Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of ATP Biosynthetic Process	Angiogenesis Apoptotic Process Axon Guidance Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Other semaphorin interactions	Netrin-1 signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS		Alzheimer's disease ( 23150908) Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood protein levels ( 30072576) C-reactive protein ( 22939635) Family history of Alzheimer's disease ( 30617256) Supraventricular ectopy ( 29618737)	Attention deficit hyperactivity disorder ( 18839057) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 33772158) Diisocyanate-induced asthma ( 25918132) Problematic alcohol use ( 32451486) Vitiligo ( 22951725)
Interacting Genes		10 interacting genes: APOA1 APOA2 APOB APOE CLU GH1 NRN1L SCGB2A2 TYROBP UNC5B	5 interacting genes: DAPK1 FLRT3 OIT3 PPP2R1B TREM2
Entrez ID		54209	219699
HPRD ID		05473	08487
Ensembl ID		ENSG00000095970	ENSG00000107731
Uniprot IDs		Q5TCX1 Q9NZC2	Q8IZJ1
PDB IDs		5ELI 5UD7 5UD8 6B8O 6XDS 6Y6C 6YMQ 6YYE 6Z0G 6Z0H 6Z0I
Enriched GO Terms of Interacting Partners?
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