TREM2 and CLU

Number of citations of the paper that reports this interaction (PubMedID 27477018)
227

Data Source:
BioGRID (pull down)

		TREM2	CLU
Description		triggering receptor expressed on myeloid cells 2	clusterin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Plasma Membrane Raft	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Golgi Apparatus Cytosol Cytoskeleton Cell Surface Membrane Platelet Alpha Granule Lumen Protein-containing Complex Spherical High-density Lipoprotein Particle Chromaffin Granule Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Cell Periphery Blood Microparticle Neurofibrillary Tangle Apical Dendrite Perinuclear Endoplasmic Reticulum Lumen
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Phosphatidylethanolamine Binding Kinase Activator Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Signaling Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding Lipoteichoic Acid Binding Lipoprotein Particle Binding Scaffold Protein Binding Sulfatide Binding Protein Tyrosine Kinase Binding	Amyloid-beta Binding Signaling Receptor Binding Protein Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding Protein Carrier Activity
	Biological Process	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Microglial Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of Inflammatory Response To Antigenic Stimulus Response To Ischemia Phagocytosis, Recognition Phagocytosis, Engulfment Humoral Immune Response Memory Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Lipid Metabolic Process Osteoclast Differentiation Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Detection Of Lipopolysaccharide Detection Of Peptidoglycan Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 6 Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Glial Cell Apoptotic Process Social Behavior CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Regulation Of Innate Immune Response Positive Regulation Of Osteoclast Differentiation Respiratory Burst After Phagocytosis Positive Regulation Of Complement Activation, Classical Pathway Astrocyte Activation Response To Axon Injury Positive Regulation Of Protein Secretion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Activation Positive Regulation Of Chemotaxis Lipid Homeostasis Regulation Of Resting Membrane Potential Positive Regulation Of Phagocytosis, Engulfment Microglial Cell Proliferation Negative Regulation Of Astrocyte Activation Pyroptosis Negative Regulation Of Fat Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Glucose Stimulus Cellular Response To Lipid Cellular Response To Hypoxia Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Dendritic Cell Differentiation Dendritic Spine Maintenance Import Into Cell Regulation Of Hippocampal Neuron Apoptotic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Complement-mediated Synapse Pruning Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Amyloid-beta Clearance By Cellular Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Inward Rectifier Potassium Channel Activity Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of P38MAPK Cascade Positive Regulation Of Microglial Cell Activation Negative Regulation Of Autophagic Cell Death Positive Regulation Of Microglial Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Low-density Lipoprotein Particle Clearance Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of ATP Biosynthetic Process	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Immune Complex Clearance Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Response To Virus Positive Regulation Of Gene Expression Protein Import Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Negative Regulation Of Cell Death Chaperone-mediated Protein Folding Microglial Cell Proliferation Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Amyloid-beta Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Cellular Response To Thapsigargin Negative Regulation Of Cellular Response To Tunicamycin Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Other semaphorin interactions	Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alzheimer's disease ( 23150908) Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood protein levels ( 30072576) C-reactive protein ( 22939635) Family history of Alzheimer's disease ( 30617256) Supraventricular ectopy ( 29618737)	Alzheimer's disease ( 19734902 19734903 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Family history of Alzheimer's disease ( 30617256) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Panic disorder ( 19165232) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		10 interacting genes: APOA1 APOA2 APOB APOE CLU GH1 NRN1L SCGB2A2 TYROBP UNC5B	59 interacting genes: ADGRF4 APP BAG6 C7 C8B C9 CBR3 CBY1 CD209 CLUAP1 CYP2E1 DISC1 DLG4 DUSP13 ELN EPPIN FOS GEMIN7 GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN KRT12 LEP LEPR LIG4 LRP1 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 MSRB1 NAT2 PAXIP1 PLXNA4 POLR1C PON1 PRNP RBBP8 RPL23 SHANK3 SRPK2 SYVN1 TGFBR1 TGFBR2 TNIK TREM2 TSC22D4 TTR UBC VHL VLDLR XRCC6 ZWINT
Entrez ID		54209	1191
HPRD ID		05473	01706
Ensembl ID		ENSG00000095970	ENSG00000120885
Uniprot IDs		Q5TCX1 Q9NZC2	P10909
PDB IDs		5ELI 5UD7 5UD8 6B8O 6XDS 6Y6C 6YMQ 6YYE 6Z0G 6Z0H 6Z0I
Enriched GO Terms of Interacting Partners?
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