TREM2 and APOA1

Number of citations of the paper that reports this interaction (PubMedID 27477018)
227

Data Source:
BioGRID (pull down)

		TREM2	APOA1
Description		triggering receptor expressed on myeloid cells 2	apolipoprotein A1
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Plasma Membrane Raft	Extracellular Region Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Extracellular Vesicle
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Phosphatidylethanolamine Binding Kinase Activator Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Signaling Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding Lipoteichoic Acid Binding Lipoprotein Particle Binding Scaffold Protein Binding Sulfatide Binding Protein Tyrosine Kinase Binding	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Chemorepellent Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Microglial Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of Inflammatory Response To Antigenic Stimulus Response To Ischemia Phagocytosis, Recognition Phagocytosis, Engulfment Humoral Immune Response Memory Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Lipid Metabolic Process Osteoclast Differentiation Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Detection Of Lipopolysaccharide Detection Of Peptidoglycan Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 6 Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Glial Cell Apoptotic Process Social Behavior CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Regulation Of Innate Immune Response Positive Regulation Of Osteoclast Differentiation Respiratory Burst After Phagocytosis Positive Regulation Of Complement Activation, Classical Pathway Astrocyte Activation Response To Axon Injury Positive Regulation Of Protein Secretion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Activation Positive Regulation Of Chemotaxis Lipid Homeostasis Regulation Of Resting Membrane Potential Positive Regulation Of Phagocytosis, Engulfment Microglial Cell Proliferation Negative Regulation Of Astrocyte Activation Pyroptosis Negative Regulation Of Fat Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Glucose Stimulus Cellular Response To Lipid Cellular Response To Hypoxia Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Dendritic Cell Differentiation Dendritic Spine Maintenance Import Into Cell Regulation Of Hippocampal Neuron Apoptotic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Complement-mediated Synapse Pruning Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Amyloid-beta Clearance By Cellular Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Inward Rectifier Potassium Channel Activity Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of P38MAPK Cascade Positive Regulation Of Microglial Cell Activation Negative Regulation Of Autophagic Cell Death Positive Regulation Of Microglial Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Low-density Lipoprotein Particle Clearance Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of ATP Biosynthetic Process	Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Negative Regulation Of Cytokine Production Involved In Immune Response Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Glucocorticoid Metabolic Process Response To Xenobiotic Stimulus Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Esterification Positive Regulation Of Cholesterol Efflux Positive Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Peripheral Nervous System Axon Regeneration Protein Oxidation Peptidyl-methionine Modification Lipid Storage Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Animal Organ Regeneration Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Response To Estrogen Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Protein Stabilization Negative Chemotaxis Positive Regulation Of Lipoprotein Lipase Activity Vitamin Transport Positive Regulation Of Hydrolase Activity Positive Regulation Of Stress Fiber Assembly Phospholipid Homeostasis Negative Regulation Of Lipase Activity Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Intermembrane Lipid Transfer Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phospholipid Efflux
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Other semaphorin interactions	Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alzheimer's disease ( 23150908) Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood protein levels ( 30072576) C-reactive protein ( 22939635) Family history of Alzheimer's disease ( 30617256) Supraventricular ectopy ( 29618737)	Allergic rhinitis ( 30013184) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Body mass index ( 31978080) Cholesterol, total ( 24097068 19060911 20686565) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Diastolic blood pressure ( 27841878) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 24097068 20864672 19060906 20686565 26582766) HDL cholesterol levels ( 28334899) Hearing function ( 25060954) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 27599772 23505323) Infantile hypertrophic pyloric stenosis ( 23989729) LDL cholesterol ( 24097068 18179892 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 32759990) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 26763881 28371326 32759990 28548082) Triglycerides ( 24097068 19074352 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20139978 20686565 26582766) Very low density lipoprotein cholesterol levels ( 28548082)
Interacting Genes		10 interacting genes: APOA1 APOA2 APOB APOE CLU GH1 NRN1L SCGB2A2 TYROBP UNC5B	37 interacting genes: ABCA1 ABCA13 AKT2 APOB APOC1 APOF APOL1 APP ATP5F1B BRAP CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR HSP90AA1 JAK3 LBP LCAT MAP7D1 NAXE NDRG1 PCMT1 PDE1A PLTP POLR1H PON1 SAA2 SCARB1 SPP1 TNFRSF10C TOMM20 TREM2 TTR VKORC1
Entrez ID		54209	335
HPRD ID		05473	02517
Ensembl ID		ENSG00000095970	ENSG00000118137
Uniprot IDs		Q5TCX1 Q9NZC2	A0A024R3E3 P02647
PDB IDs		5ELI 5UD7 5UD8 6B8O 6XDS 6Y6C 6YMQ 6YYE 6Z0G 6Z0H 6Z0I	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2MSC 2MSD 2MSE 2N5E 3K2S 3R2P 4V6M 6CC9 6CCH 6CCX 6CLZ 6CM1 6PTS 6PTW 6W4E 6W4F 7KJR
Enriched GO Terms of Interacting Partners?
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