CNTN5 and VRK2

		CNTN5	VRK2
Description		contactin 5	VRK serine/threonine kinase 2
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane GABA-ergic Synapse Anchored Component Of Presynaptic Membrane	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function		Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Sensory Perception Of Sound Presynapse Assembly	Protein Phosphorylation Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Alcohol dependence ( 26365420) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 29273806) Atrial fibrillation ( 17903304) Behcet's disease ( 27548383) Bipolar disorder and schizophrenia ( 20889312) Blood protein levels ( 30072576 29875488 28240269) Bone mineral density (femoral neck) ( 26911590) Cardiorespiratory fitness (800m run time) ( 32572135) Carotid intima media thickness x smoking interaction ( 32117412) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronotype ( 30696823) Diastolic blood pressure ( 27841878) Factor VII activity ( 30642921) Feeling miserable ( 29500382) Fructosamine levels ( 29844224) Glycated hemoglobin levels ( 28898252) Gout vs. Hyperuricemia ( 31289104) HDL cholesterol levels in HIV infection ( 33109212) Immune reponse to smallpox (secreted IL-2) ( 22610502) Loneliness (multivariate analysis) ( 27629369) Major depressive disorder x sex interaction ( 34099189) Myopia (pathological) ( 23049088) Neurological blood protein biomarker levels ( 31320639) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Plasma kynurenine levels in major depressive disorder ( 29317604) Spatial memory ( 31596458) Total glycated albumin levels ( 29844224) Volumetric brain MRI ( 17903297) Waist-hip ratio ( 25673412)	Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Ambidextrousness ( 32989287) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Depression ( 33859377 29700475) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hip circumference adjusted for BMI ( 34021172) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Problematic alcohol use ( 32451486) Schizophrenia ( 28991256 25056061 19571808 29483656 27922604 30285260) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321) Smoking initiation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		2 interacting genes: FDX1 VRK2	25 interacting genes: AQP6 ASB3 BABAM2 CCT2 CCT4 CDC42 CNTN5 DHDDS DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 OGT PLD3 PTTG1 RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88
Entrez ID		53942	7444
HPRD ID		06241	03702
Ensembl ID		ENSG00000149972	ENSG00000028116
Uniprot IDs		O94779	A8K9L2 Q86Y07
PDB IDs		4N68 5E52	2V62 5UU1 6NCG
Enriched GO Terms of Interacting Partners?
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