CDK16 and ATRIP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CDK16	ATRIP
Description		cyclin dependent kinase 16	ATR interacting protein
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Microtubule Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection	Nucleoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Spermatogenesis Growth Hormone Secretion Neuron Projection Development Regulation Of Cell Cycle Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	DNA Damage Checkpoint Signaling DNA Repair
Pathways			Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs		(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		18 interacting genes: APP APPBP2 ATRIP BAG6 CCND3 CDK5 CDK5R1 PJA1 PRKACA S100A10 SEC23A SIRPA YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB14	22 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2 ZBTB14
Entrez ID		5127	84126
HPRD ID		02409
Ensembl ID		ENSG00000102225	ENSG00000164053
Uniprot IDs		A0A024R183 A0A140VK97 Q00536 Q9BRL4	A0A024R2U4 A0A024R307 Q8WXE1
PDB IDs		3MTL 5G6V	4IGK 4NB3 5YZ0
Enriched GO Terms of Interacting Partners?
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