ATRIP and CEP164

Number of citations of the paper that reports this interaction (PubMedID 18283122)
37

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ATRIP	CEP164
Description		ATR interacting protein	centrosomal protein 164
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Extracellular Space Nucleoplasm Centrosome Centriole Cytosol Ciliary Transition Fiber
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair	DNA Repair Cell Cycle Cell Division Cilium Assembly
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Apolipoprotein A1 levels ( 32203549) Diastolic blood pressure ( 30578418) Diffusing capacity of carbon monoxide ( 30694715) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Pulse pressure ( 28135244 27841878 30578418)
Interacting Genes		22 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2 ZBTB14	6 interacting genes: ATP5MG ATR ATRIP CLP1 MAPK14 UBC
Entrez ID		84126	22897
HPRD ID			10854
Ensembl ID		ENSG00000164053	ENSG00000110274
Uniprot IDs		A0A024R2U4 A0A024R307 Q8WXE1	Q9UPV0
PDB IDs		4IGK 4NB3 5YZ0
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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