CDK16 and YWHAH

Number of citations of the paper that reports this interaction (PubMedID 9799109)
5

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		CDK16	YWHAH
Description		cyclin dependent kinase 16	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Microtubule Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Spermatogenesis Growth Hormone Secretion Neuron Projection Development Regulation Of Cell Cycle Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Substantia Nigra Development Cellular Protein Localization Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs		(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib	Phenethyl Isothiocyanate
Diseases
GWAS			Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)
Interacting Genes		18 interacting genes: APP APPBP2 ATRIP BAG6 CCND3 CDK5 CDK5R1 PJA1 PRKACA S100A10 SEC23A SIRPA YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB14	66 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		5127	7533
HPRD ID		02409	00215
Ensembl ID		ENSG00000102225	ENSG00000128245
Uniprot IDs		A0A024R183 A0A140VK97 Q00536 Q9BRL4	A0A024R1K7 Q04917 Q9H4N8
PDB IDs		3MTL 5G6V	2C63 2C74
Enriched GO Terms of Interacting Partners?
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