MAP3K11 and MAP2K4

Number of citations of the paper that reports this interaction (PubMedID 10187804)
34

Data Source:
BioGRID (enzymatic study)

		MAP3K11	MAP2K4
Description		mitogen-activated protein kinase kinase kinase 11	mitogen-activated protein kinase kinase 4
Image
GO Annotations	Cellular Component	Centrosome Cytosol Microtubule Membrane	Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Protein Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation	MAPK Cascade Positive Regulation Of Protein Phosphorylation Apoptotic Process Signal Transduction JNK Cascade Response To Wounding Peptidyl-tyrosine Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Cellular Senescence Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)	Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		33 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 FKBP2 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 MYO7A NEIL1 PIN1 PNLIPRP2 RAC1 RHOG SH3RF1 STUB1 TIA1 TRAF6 TSGA10IP	44 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK7 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC
Entrez ID		4296	6416
HPRD ID		02502	03213
Ensembl ID		ENSG00000173327	ENSG00000065559
Uniprot IDs		A0A024R5E6 Q16584	P45985
PDB IDs		5K26 5K28 6AQB 6CQ7	3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?
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