MAP3K11 and NEIL1

		MAP3K11	NEIL1
Description		mitogen-activated protein kinase kinase kinase 11	nei like DNA glycosylase 1
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GO Annotations	Cellular Component	Centrosome Cytosol Microtubule Membrane	Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein C-terminus Binding Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation	Base-excision Repair Base-excision Repair, Gap-filling Response To Oxidative Stress Negative Regulation Of Nuclease Activity Depyrimidination
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective Base Excision Repair Associated with NEIL1
Drugs		Fostamatinib	Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		33 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 FKBP2 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 MYO7A NEIL1 PIN1 PNLIPRP2 RAC1 RHOG SH3RF1 STUB1 TIA1 TRAF6 TSGA10IP	7 interacting genes: APP HUS1 LIG3 MAP3K11 POLB RAD1 XRCC1
Entrez ID		4296	79661
HPRD ID		02502	12314
Ensembl ID		ENSG00000173327	ENSG00000140398
Uniprot IDs		A0A024R5E6 Q16584	Q96FI4
PDB IDs		5K26 5K28 6AQB 6CQ7	1TDH 4NRV 5ITQ 5ITR 5ITT 5ITU 5ITX 5ITY
Enriched GO Terms of Interacting Partners?
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