MAP3K11 and TIA1

		MAP3K11	TIA1
Description		mitogen-activated protein kinase kinase kinase 11	TIA1 cytotoxic granule associated RNA binding protein
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GO Annotations	Cellular Component	Centrosome Cytosol Microtubule Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Stress Granule Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	RNA Binding Protein Binding Poly(A) Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation	Negative Regulation Of Cytokine Production Apoptotic Process Negative Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants	FGFR2 alternative splicing
Drugs		Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)	Acne (severe) ( 24927181) Male-pattern baldness ( 28196072)
Interacting Genes		33 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 FKBP2 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 MYO7A NEIL1 PIN1 PNLIPRP2 RAC1 RHOG SH3RF1 STUB1 TIA1 TRAF6 TSGA10IP	3 interacting genes: FASTK MAP3K11 WBP4
Entrez ID		4296	7072
HPRD ID		02502	04626
Ensembl ID		ENSG00000173327	ENSG00000116001
Uniprot IDs		A0A024R5E6 Q16584	P31483
PDB IDs		5K26 5K28 6AQB 6CQ7	2MJN 3BS9 5ITH 5O2V 5O3J 6ELD
Enriched GO Terms of Interacting Partners?
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