MAP3K11 and KIF17

Number of citations of the paper that reports this interaction (PubMedID 9427749)
71

Data Source:
BioGRID (two hybrid)

		MAP3K11	KIF17
Description		mitogen-activated protein kinase kinase kinase 11	kinesin family member 17
Image			No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Microtubule Membrane	Microtubule Organizing Center Cytosol Kinesin Complex Microtubule Cilium Axoneme Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Basal Body Neuron Projection Periciliary Membrane Compartment
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Microtubule Motor Activity ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation	Microtubule-based Movement Protein Transport Vesicle-mediated Transport Cell Projection Organization Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants	Intraflagellar transport Assembly and cell surface presentation of NMDA receptors
Drugs		Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)	Ceramide levels (C24:0) ( 32489964) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		33 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 FKBP2 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 MYO7A NEIL1 PIN1 PNLIPRP2 RAC1 RHOG SH3RF1 STUB1 TIA1 TRAF6 TSGA10IP	8 interacting genes: APBA1 FHL5 FXR1 GFI1B MAP3K10 MAP3K11 PHAF1 XPO1
Entrez ID		4296	57576
HPRD ID		02502	10388
Ensembl ID		ENSG00000173327	ENSG00000117245
Uniprot IDs		A0A024R5E6 Q16584	A0A0A0MRS8 Q9P2E2
PDB IDs		5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?
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