MFAP4 and SFTPD

Number of citations of the paper that reports this interaction (PubMedID 10542261)
14

Data Source:
HPRD (in vivo)

		MFAP4	SFTPD
Description		microfibril associated protein 4	surfactant protein D
Image		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Elastic Fiber	Extracellular Region Collagen Trimer Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endocytic Vesicle Clathrin-coated Endocytic Vesicle
	Molecular Function	Antigen Binding Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Derivative Binding	Protein Binding Carbohydrate Binding
	Biological Process	Complement Activation, Lectin Pathway Cell Adhesion UV Protection Regulation Of Collagen Metabolic Process Elastic Fiber Assembly Cellular Response To UV-B Supramolecular Fiber Organization	Regulation Of Cytokine Production Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Induction Of Bacterial Agglutination Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Negative Regulation By Host Of Symbiont Catalytic Activity Reactive Oxygen Species Metabolic Process Regulation Of Adhesion Of Symbiont To Host Epithelial Cell
Pathways		Molecules associated with elastic fibres	Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs			Beta-D-Glucose
Diseases
GWAS		Youthful appearance (self-reported) ( 32339537)	Chronic obstructive pulmonary disease ( 28166215 30804561 33909500) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		3 interacting genes: MAPK7 RNF115 SFTPD	12 interacting genes: CCN1 DCN DMBT1 GPA33 KCNMA1 LBR MFAP4 PLAU PLXNA3 RBX1 SFTPA1 SMR3B
Entrez ID		4239	6441
HPRD ID		02789	01522
Ensembl ID		ENSG00000166482	ENSG00000133661
Uniprot IDs		A0A024QZ34 P55083	P35247
PDB IDs			1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS
Enriched GO Terms of Interacting Partners?
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