SFTPD and CCN1

		SFTPD	CCN1
Description		surfactant protein D	cellular communication network factor 1
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endocytic Vesicle Clathrin-coated Endocytic Vesicle	Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Carbohydrate Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding Heparin Binding Extracellular Matrix Binding
	Biological Process	Regulation Of Cytokine Production Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Induction Of Bacterial Agglutination Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Negative Regulation By Host Of Symbiont Catalytic Activity Reactive Oxygen Species Metabolic Process Regulation Of Adhesion Of Symbiont To Host Epithelial Cell	Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Intussusceptive Angiogenesis Atrioventricular Valve Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Ventricular Septum Development Chemotaxis Cell Adhesion Signal Transduction Positive Regulation Of Phospholipase Activity Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Wound Healing, Spreading Of Cells Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Atrial Septum Morphogenesis Negative Regulation Of Cell Death Chondroblast Differentiation Chorio-allantoic Fusion Labyrinthine Layer Blood Vessel Development Positive Regulation Of Cartilage Development Regulation Of ERK1 And ERK2 Cascade Reactive Oxygen Species Metabolic Process Positive Regulation Of Ceramide Biosynthetic Process
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Beta-D-Glucose
Diseases
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561 33909500) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 30423114 24390342)	Appendicular lean mass ( 33097823)
Interacting Genes		12 interacting genes: CCN1 DCN DMBT1 GPA33 KCNMA1 LBR MFAP4 PLAU PLXNA3 RBX1 SFTPA1 SMR3B	6 interacting genes: CDC42 ITGAV ITGB5 SFTPD SMPD2 UBQLN2
Entrez ID		6441	3491
HPRD ID		01522	09089
Ensembl ID		ENSG00000133661	ENSG00000142871
Uniprot IDs		P35247	O00622 Q6FI18
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS	4D0Z 4D11
Enriched GO Terms of Interacting Partners?
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