SFTPD and SFTPA1

Number of citations of the paper that reports this interaction (PubMedID 10101009)
34

Data Source:
BioGRID (biochemical)

		SFTPD	SFTPA1
Description		surfactant protein D	surfactant protein A1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endocytic Vesicle Clathrin-coated Endocytic Vesicle	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Lamellar Body Clathrin-coated Endocytic Vesicle
	Molecular Function	Protein Binding Carbohydrate Binding	Lipid Transporter Activity Protein Binding Carbohydrate Binding
	Biological Process	Regulation Of Cytokine Production Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Induction Of Bacterial Agglutination Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Negative Regulation By Host Of Symbiont Catalytic Activity Reactive Oxygen Species Metabolic Process Regulation Of Adhesion Of Symbiont To Host Epithelial Cell	Lipid Transport Respiratory Gaseous Exchange By Respiratory System Opsonization
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs		Beta-D-Glucose	2-(N-morpholino)ethanesulfonic acid
Diseases
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561 33909500) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		12 interacting genes: CCN1 DCN DMBT1 GPA33 KCNMA1 LBR MFAP4 PLAU PLXNA3 RBX1 SFTPA1 SMR3B	3 interacting genes: DMBT1 PRDX6 SFTPD
Entrez ID		6441	653509
HPRD ID		01522	19256
Ensembl ID		ENSG00000133661	ENSG00000122852
Uniprot IDs		P35247	A0A024QZP2 B4DNP6 Q8IWL2
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS
Enriched GO Terms of Interacting Partners?
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