A1CF and APOBEC1

Number of citations of the paper that reports this interaction (PubMedID 10669759)
94

Data Source:
HPRD (in vivo, in vitro)

		A1CF	APOBEC1
Description		APOBEC1 complementation factor	apolipoprotein B mRNA editing enzyme catalytic subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding	RNA Binding MRNA Binding Cytidine Deaminase Activity Cytosine Deaminase Activity Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Domain Specific Binding Ribonucleoprotein Complex Binding
	Biological Process	MRNA Processing Embryo Implantation MRNA Localization Resulting In Posttranscriptional Regulation Of Gene Expression Cytidine To Uridine Editing MRNA Modification Protein Stabilization	RNA Processing MRNA Processing Lipid Metabolic Process Response To Osmotic Stress Response To Xenobiotic Stimulus Cytidine Deamination Response To Zinc Ion Cytidine To Uridine Editing MRNA Modification Cellular Response To Insulin Stimulus Response To Ethanol Regulation Of Catalytic Activity Response To Calcium Ion Defense Response To Virus DNA Cytosine Deamination DNA Demethylation Negative Regulation Of DNA Methylation-dependent Heterochromatin Assembly Positive Regulation Of MRNA Modification
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gamma glutamyl transferase levels ( 33339817) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Narcolepsy with cataplexy ( 25986216) Serum uric acid levels ( 30993211) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 31985003 31578528 23263486) Urate levels in lean individuals ( 25811787)	Body mass index ( 28552196) Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899)
Interacting Genes		26 interacting genes: APOBEC1 C19orf54 C9orf24 CAVIN2 CELF2 CYSRT1 DOK3 ECM1 EIF4G1 FHL2 FHL3 HSPB2 HSPB2-C11orf52 KHSRP KLHDC7B KRT31 KRT34 METTL27 OIP5 PLEKHG4 POGZ REL RIMBP3C SYNCRIP TNPO2 TRAF1	17 interacting genes: A1CF APOBEC2 BAG4 CACNA1I CDK6 CELF2 DNAJB11 DND1 HNRNPF HNRNPK KPNA2 KRTAP19-5 KRTAP6-1 KRTAP6-2 NOTO SYNCRIP UFSP2
Entrez ID		29974	339
HPRD ID		10627	02531
Ensembl ID		ENSG00000148584	ENSG00000111701
Uniprot IDs		A0A024QZI9 A0A024QZJ5 A0A024QZM7 B4E1E3 F8W9F8 Q9NQ94	P41238
PDB IDs		2CPD	6X91
Enriched GO Terms of Interacting Partners?
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