PRAME and XRN2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)

		PRAME	XRN2
Description		PRAME nuclear receptor transcriptional regulator	5'-3' exoribonuclease 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Nucleolus Membrane Aggresome
	Molecular Function	Protein Binding Retinoic Acid Receptor Binding Ubiquitin Ligase-substrate Adaptor Activity	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Apoptotic Process Positive Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of Growth Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		9 interacting genes: ELOB ELOC FBXO7 RARA RBX1 STK19 UBC XRN2 ZNF408	36 interacting genes: ALDH1B1 ATRN BFSP1 COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MAGEA11 MOCS3 MRPL4 MRPS10 OGT PGM1 PLEKHF2 PRAME PSMA3 PYGB RAB14 SETMAR STK39 TARDBP TIPARP TOLLIP TTC23 UPF2
Entrez ID		23532	22803
HPRD ID		05820	10309
Ensembl ID		ENSG00000185686	ENSG00000088930
Uniprot IDs		A0A024R1E6 B7Z7K8 B7Z986 B7ZAT0 P78395	B4DZC3 Q9H0D6
PDB IDs
Enriched GO Terms of Interacting Partners?
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