XRN2 and SETMAR

		XRN2	SETMAR
Description		5'-3' exoribonuclease 2	SET domain and mariner transposase fusion gene
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Condensed Chromosome Nucleus Nucleolus Site Of Double-strand Break
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Protein Homodimerization Activity DNA Topoisomerase Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	DNA Double-strand Break Processing DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Via Nonhomologous End Joining Cell Population Proliferation Histone H3-K36 Methylation DNA Integration Replication Fork Processing Mitotic DNA Integrity Checkpoint Signaling Histone H3-K4 Methylation Regulation Of Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Histone H3-K36 Dimethylation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Chromosome Organization
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Fractures (paediatric) ( 32742401) Midgestational circulating levels of PCBs ( 28235828) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		36 interacting genes: ALDH1B1 ATRN BFSP1 COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MAGEA11 MOCS3 MRPL4 MRPS10 OGT PGM1 PLEKHF2 PRAME PSMA3 PYGB RAB14 SETMAR STK39 TARDBP TIPARP TOLLIP TTC23 UPF2	2 interacting genes: H3-5 XRN2
Entrez ID		22803	6419
HPRD ID		10309	10225
Ensembl ID		ENSG00000088930	ENSG00000170364
Uniprot IDs		B4DZC3 Q9H0D6	B4DND2 Q53H47 Q96H41
PDB IDs			3BO5 3F2K 3K9J 3K9K
Enriched GO Terms of Interacting Partners?
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