XRN2 and TIPARP

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
HPRD (two hybrid)

		XRN2	TIPARP
Description		5'-3' exoribonuclease 2	TCDD inducible poly(ADP-ribose) polymerase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Nucleus
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	Cis-regulatory Region Sequence-specific DNA Binding NAD+ ADP-ribosyltransferase Activity Metal Ion Binding Protein ADP-ribosylase Activity
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Vasculogenesis Kidney Development Protein ADP-ribosylation Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Negative Regulation Of Gene Expression Hemopoiesis Positive Regulation Of Protein Catabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Smooth Muscle Tissue Development Roof Of Mouth Development Face Morphogenesis Protein Auto-ADP-ribosylation Cellular Response To Organic Cyclic Compound Protein Mono-ADP-ribosylation Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Adult body size ( 32376654) Central corneal thickness ( 29760442) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Chronotype ( 30696823) Epithelial ovarian cancer ( 25581431) Malaria ( 31844061) Nose size ( 27182965) Ovarian cancer ( 20852632) Testicular germ cell tumor ( 28604732) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		36 interacting genes: ALDH1B1 ATRN BFSP1 COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MAGEA11 MOCS3 MRPL4 MRPS10 OGT PGM1 PLEKHF2 PRAME PSMA3 PYGB RAB14 SETMAR STK39 TARDBP TIPARP TOLLIP TTC23 UPF2	2 interacting genes: ATM XRN2
Entrez ID		22803	25976
HPRD ID		10309	18192
Ensembl ID		ENSG00000088930	ENSG00000163659
Uniprot IDs		B4DZC3 Q9H0D6	Q05BQ2 Q7Z3E1
PDB IDs
Enriched GO Terms of Interacting Partners?
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