XRN2 and ALDH1B1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)

		XRN2	ALDH1B1
Description		5'-3' exoribonuclease 2	aldehyde dehydrogenase 1 family member B1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	Aldehyde Dehydrogenase (NAD+) Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity NAD Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Carbohydrate Metabolic Process Ethanol Catabolic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol	Ethanol oxidation
Drugs			NADH
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Clostridioides difficle infection in antibiotics-users ( 33841421) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		36 interacting genes: ALDH1B1 ATRN BFSP1 COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MAGEA11 MOCS3 MRPL4 MRPS10 OGT PGM1 PLEKHF2 PRAME PSMA3 PYGB RAB14 SETMAR STK39 TARDBP TIPARP TOLLIP TTC23 UPF2	5 interacting genes: EXOSC10 FABP2 FES OGT XRN2
Entrez ID		22803	219
HPRD ID		10309	00005
Ensembl ID		ENSG00000088930	ENSG00000137124
Uniprot IDs		B4DZC3 Q9H0D6	A0A384MTJ7 P30837
PDB IDs
Enriched GO Terms of Interacting Partners?
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