PRAME and STK19

Number of citations of the paper that reports this interaction (PubMedID 14667819)
36

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		PRAME	STK19
Description		PRAME nuclear receptor transcriptional regulator	serine/threonine kinase 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cul2-RING Ubiquitin Ligase Complex	Nucleus Nuclear Speck
	Molecular Function	Protein Binding Retinoic Acid Receptor Binding Ubiquitin Ligase-substrate Adaptor Activity	Protein Serine/threonine Kinase Activity ATP Binding Small GTPase Binding Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Apoptotic Process Positive Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of Growth Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway	Protein Phosphorylation Positive Regulation Of Ras Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23577725) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Broad depression or schizophrenia ( 30626913) Bullous pemphigoid ( 34011352) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Disease progression in age-related macular degeneration ( 29346644) Hematology traits ( 23263863) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Prostate cancer ( 23535732) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: ELOB ELOC FBXO7 RARA RBX1 STK19 UBC XRN2 ZNF408	14 interacting genes: BHLHE40 MAB21L3 PFDN5 PICK1 POLE POLR2G PRAME SF3B4 SLC29A1 SP3 TBRG4 TRIM23 VIM ZRANB1
Entrez ID		23532	8859
HPRD ID		05820	07281
Ensembl ID		ENSG00000185686	ENSG00000204344
Uniprot IDs		A0A024R1E6 B7Z7K8 B7Z986 B7ZAT0 P78395	A0A1U9X8L3 P49842
PDB IDs
Enriched GO Terms of Interacting Partners?
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