UFL1 and ENY2

Number of citations of the paper that reports this interaction (PubMedID 32545848)
8

Data Source:
BioGRID (two hybrid)

		UFL1	ENY2
Description		UFM1 specific ligase 1	ENY2 transcription and export complex 2 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex Site Of Double-strand Break Neuron Projection	SAGA Complex Nucleoplasm Mitochondrion Nuclear Pore Nuclear Basket Transcription Export Complex 2 DUBm Complex
	Molecular Function	Protein Binding Protein Kinase Binding UFM1 Ligase Activity UFM1 Transferase Activity	Chromatin Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity
	Biological Process	Osteoblast Differentiation DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Histone Modification Erythrocyte Differentiation Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Inflammatory Response Hematopoietic Stem Cell Differentiation Positive Regulation Of Glial Cell Proliferation Reticulophagy Protein Ufmylation Response To L-glutamate Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein K69-linked Ufmylation	Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Transport Histone Deubiquitination Poly(A)+ MRNA Export From Nucleus Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	HATs acetylate histones
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Headache ( 29397368) Migraine ( 27322543) Migraine without aura ( 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Walking pace ( 33128006)	Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Night sleep phenotypes ( 27126917)
Interacting Genes		18 interacting genes: AHCY AKAP17A ATP4A CDK5RAP3 ENY2 FGB H2AC4 HINFP IRAK1BP1 IRF3 MT1M PPIL1 PTPRO TIPRL TP53 TSC22D3 UFC1 ZNF219	7 interacting genes: APP ATXN7L3 ATXN7L3B C11orf49 HNRNPA2B1 MCM3AP UFL1
Entrez ID		23376	56943
HPRD ID		11109	13121
Ensembl ID		ENSG00000014123	ENSG00000120533
Uniprot IDs		O94874	A0A024R9D9 Q9NPA8
PDB IDs			4DHX
Enriched GO Terms of Interacting Partners?
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