SETMAR and H3-5

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		SETMAR	H3-5
Description		SET domain and mariner transposase fusion gene	H3.5 histone
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleolus Site Of Double-strand Break	Nucleosome Euchromatin Barr Body Nucleus
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Protein Homodimerization Activity DNA Topoisomerase Binding Histone Methyltransferase Activity (H3-K36 Specific)	Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	DNA Double-strand Break Processing DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Via Nonhomologous End Joining Cell Population Proliferation Histone H3-K36 Methylation DNA Integration Replication Fork Processing Mitotic DNA Integrity Checkpoint Signaling Histone H3-K4 Methylation Regulation Of Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Histone H3-K36 Dimethylation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Chromosome Organization	Osteoblast Differentiation Nucleus Organization Spermatid Development Single Fertilization Embryo Implantation Cell Population Proliferation Male Gonad Development Positive Regulation Of Cell Growth Pericentric Heterochromatin Assembly Subtelomeric Heterochromatin Assembly Multicellular Organism Growth Muscle Cell Differentiation Oogenesis Regulation Of Centromere Complex Assembly Negative Regulation Of Chromosome Condensation
Pathways
Drugs
Diseases
GWAS		Fractures (paediatric) ( 32742401) Midgestational circulating levels of PCBs ( 28235828) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		2 interacting genes: H3-5 XRN2	15 interacting genes: DAXX DNAJC9 FBLIM1 KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1
Entrez ID		6419	440093
HPRD ID		10225	18443
Ensembl ID		ENSG00000170364	ENSG00000188375
Uniprot IDs		B4DND2 Q53H47 Q96H41	Q6NXT2
PDB IDs		3BO5 3F2K 3K9J 3K9K	2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L 6OI3
Enriched GO Terms of Interacting Partners?
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