SETMAR

Description		SET domain and mariner transposase fusion gene
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleolus Site Of Double-strand Break
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Protein Homodimerization Activity DNA Topoisomerase Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	DNA Double-strand Break Processing DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Via Nonhomologous End Joining Cell Population Proliferation Histone H3-K36 Methylation DNA Integration Replication Fork Processing Mitotic DNA Integrity Checkpoint Signaling Histone H3-K4 Methylation Regulation Of Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Histone H3-K36 Dimethylation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Chromosome Organization
Pathways
Drugs
Diseases
GWAS		Fractures (paediatric) ( 32742401) Midgestational circulating levels of PCBs ( 28235828) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		2 interacting genes: H3-5 XRN2
Entrez ID		6419
HPRD ID		10225
Ensembl ID		ENSG00000170364
Uniprot IDs		B4DND2 Q53H47 Q96H41
PDB IDs		3BO5 3F2K 3K9J 3K9K
Enriched GO Terms of Interacting Partners?
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