ABCB7 and RAP1GDS1

		ABCB7	RAP1GDS1
Description		ATP binding cassette subfamily B member 7	Rap1 GTPase-GDP dissociation stimulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Heme Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity ABC-type Iron-sulfur Cluster Transporter Activity	GTPase Activator Activity Protein Binding
	Biological Process	Cellular Iron Ion Homeostasis Heme Transport Iron-sulfur Cluster Assembly Iron Ion Transmembrane Transport Iron Ion Homeostasis Transmembrane Transport Positive Regulation Of Heme Biosynthetic Process Iron-sulfur Cluster Export From The Mitochondrion Positive Regulation Of Iron-sulfur Cluster Assembly Negative Regulation Of Reactive Oxygen Species Biosynthetic Process	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways		Mitochondrial ABC transporters Cytosolic iron-sulfur cluster assembly	RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		4 interacting genes: APP FECH RAP1GDS1 UBC	28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451
Entrez ID		22	5910
HPRD ID		02137	11763
Ensembl ID		ENSG00000131269	ENSG00000138698
Uniprot IDs		A0A087WW65 A0A0S2Z2Z3 O75027	B3KNU0 P52306 Q6U7G8
PDB IDs			5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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