AKT1 and PKN2

  • Number of citations of the paper that reports this interaction (PubMedID 10926925)
  • 23
  • Data Source:
  • HPRD (two hybrid, in vitro, in vivo)

AKT1

PKN2

Description AKT serine/threonine kinase 1 protein kinase N2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Age at first sexual intercourse ( 34211149)
  • Alanine aminotransferase levels ( 33547301 34315874)
  • Aspartate aminotransferase levels ( 33547301 34315874)
  • Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)
  • Coronary artery disease ( 29212778)
  • Diastolic blood pressure ( 27841878)
  • General risk tolerance (MTAG) ( 30643258)
  • Heel bone mineral density ( 30598549 28869591)
  • Height ( 20881960 25282103 31562340)
  • Intraocular pressure ( 29617998)
  • Liver enzyme levels (alanine transaminase) ( 33972514)
  • Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757)
  • Narcolepsy ( 23459209)
  • Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095)
  • Paclitaxel disposition in epithelial ovarian cancer ( 29367611)
  • Periodontal microbiota ( 22699663)
  • Photic sneeze reflex ( 27182965)
  • Pulse pressure ( 27841878)
  • Red blood cell count ( 32888494)
  • Refractive error ( 32231278)
  • Response to fenofibrate (LDL cholesterol levels) ( 27002377)
  • Rosacea symptom severity ( 29771307)
  • Serum protein levels (sST2) ( 23999434)
  • Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
  • Systolic blood pressure ( 30224653 27841878)
  • Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
  • Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
  • Waist circumference adjusted for body mass index ( 34021172)
  • White matter hyperintensity volume ( 33293549)
  • White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes 325 interacting genes: ACAP1 ACAT2 ADCY10 AGAP2 AGR3 AHNAK AHSA1 AKT1S1 AKT2 AKTIP ALYREF APLP2 APOC1 APOH APP APPL1 AR ARAF ARFIP2 ARNT ATXN1 AURKA BABAM1 BAD BCL10 BCL2L1 BCL2L11 BCL3 BECN1 BEX1 BLVRA BPGM BRAF BRCA1 BUB1 CAMKK1 CARHSP1 CASC3 CASP3 CASP9 CBLC CCDC88A CCND2 CCNE1 CCNF CCNI CD44 CDC37 CDC42 CDH1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CEP57L1 CEP76 CHEK1 CHUK CLASP2 CLIP3 CLK2 CNOT9 CREB1 CREBBP CSNK2A1 CTDSP2 CTNNA1 CTNNB1 CYLD DAB2IP DCTN1 DDIT4L DLC1 DNAJB1 DNMT1 EEF1G EIF4EBP1 EMSY ENO2 EP300 EPHA2 EPSTI1 ERBB2 ESR1 ESR2 EZH2 FAF1 FANCA FANCI FASN FBXO31 FBXW7 FGFR4 FOXO1 FOXO3 FOXO4 FUS GAB2 GATA1 GATA2 GET4 GFAP GJA1 GLIS2 GRB10 GRIN2A GSK3A GSK3B H2BC21 H2BC3 HIF1A HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB IL13RA2 IL24 ILK IMPDH2 IRAK1 IRS1 ITGB3 ITPR1 ITPR3 ITSN1 IWS1 JADE1 KANK1 KAT2A KAT2B KAT6A KDELR2 KLHL3 KMT2D KRT10 LANCL2 LATS2 LRRK2 LTB4R2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K11 MAP3K5 MAP3K8 MAPK14 MAPK8 MAPK8IP1 MAPK9 MAPKAP1 MAPKAPK2 MAPT MATK MDM2 MDM4 MESD METTL1 MIS12 MLH3 MRC2 MS4A2 MSH2 MST1R MTA3 MTCP1 MTOR MTUS2 MUL1 MXD1 MYC NCF2 NCOA4 NCOR2 NEDD4 NF1 NF2 NGB NLGN3 NOL4 NOS3 NOTCH1 NR4A1 NRAS NSD3 OSGIN1 PAK1 PCK1 PDE3A PDE3B PDGFRA PDHB PDK1 PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PFKP PHB2 PI4K2B PIAS1 PIAS2 PICK1 PIK3CA PIK3R1 PIP5K1C PKN2 PLCG1 PLEKHO1 PLP1 PLXNA1 PMS2 PPARGC1B PPL PPM1A PPP2CA PPP2R1A PRG2 PRKCQ PRKCZ PRKDC PSMC5 PTEN PTGDS PTPA PTPN1 PTPN11 PTPN3 PYGO2 RAB3D RAC1 RAF1 RARA RASL10B RASSF1 RGCC RHEBL1 RNF11 RNF115 RPS6KB1 S100A14 S1PR1 SERPINB5 SETDB1 SH2B2 SH3RF1 SIRPA SIRT1 SIRT6 SKI SKP2 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SNCB SORBS2 SOX4 SP1 SP3 SRC SRPK2 SRR SSH1 ST14 STAT1 STK11 STK3 STK4 SULT4A1 SUPT6H SYTL1 TBC1D4 TBC1D7 TCL1A TCL1B TCL6 TEAD2 TERF2IP TERT TFF1 THEM4 THRSP TLR2 TMCC2 TNFRSF1A TNFSF11 TNK2 TOPBP1 TP53 TRIB3 TRIM13 TRMT2B TSC1 TSC2 TTC3 UBE2S UCHL1 USP4 UXS1 VEGFA VHL VIM WNK1 WNK4 XAF1 XIAP YAP1 YBX1 YWHAZ ZFP36L1 ZHX1 ZNF691 ZRANB1 19 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTBP2 PTPN13 RHOA SUMO2
Entrez ID 207 5586
HPRD ID 01261 03972
Ensembl ID ENSG00000142208 ENSG00000065243
Uniprot IDs B0LPE5 B3KVH4 P31749 Q16513
PDB IDs 1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV 6BUU 6CCY 6HHF 6HHG 6HHH 6HHI 6HHJ 6NPZ 6S9W 6S9X 4CRS 4RRV 6CCY 6GBE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?