EFHC1 and SYNGAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EFHC1	SYNGAP1
Description		EF-hand domain containing 1	synaptic Ras GTPase activating protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Axoneme Neuronal Cell Body Mitotic Spindle	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Protein C-terminus Binding Alpha-tubulin Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Mitotic Cytokinesis Mitotic Spindle Organization Cerebral Cortex Cell Migration Regulation Of Cell Division Cilium-dependent Cell Motility	Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Regulation Of GTPase Activity Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure
Pathways			Regulation of RAS by GAPs
Drugs
Diseases
GWAS		Atopic march ( 26542096) Clozapine-induced myocarditis in schizophrenia ( 32066683) Mean platelet volume ( 27863252) Perceived intensity of glucose ( 31005972) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) White blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)
Interacting Genes		67 interacting genes: C11orf45 C20orf85 CACNA1E CALCOCO2 CFAP161 CHCHD3 DOK7 EFHC2 EIF4ENIF1 FMR1 GADD45B GAS2L2 GOLGA2 HOMER3 IHO1 IKZF3 IMP3 ITGB3BP KCTD4 KRT15 KRT18 KRT75 LMO2 LRRC61 MAMDC2 MBD3L1 METTL27 MIIP MRNIP MTFR1L NQO2 NRIP3 NUP54 OIP5 PAX6 PBX1 PBX2 PMF1 PRR5L RCN1 REL RIMBP3 RNF125 SAPCD1 SELENOV SH3GLB2 SLAIN1 SNAI1 SORBS3 SPATA2 SYNGAP1 TCF4 TEKT1 TEX11 TLE5 TP53BP2 TRAF2 TRIP6 TRPM2 TSGA10IP TTC23L UBAP2 VBP1 WASF1 WHRN YJU2B ZBED1	29 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SHANK3 SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX
Entrez ID		114327	8831
HPRD ID		10583	16018
Ensembl ID		ENSG00000096093	ENSG00000197283
Uniprot IDs		B2CKC5 Q5JVL4	A0A1U9X8L0 B7ZCA0 Q96PV0
PDB IDs
Enriched GO Terms of Interacting Partners?
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