CHEK2 and MDC1

Number of citations of the paper that reports this interaction (PubMedID 12607004)
122

Data Source:
HPRD (in vivo)

		CHEK2	MDC1
Description		checkpoint kinase 2	mediator of DNA damage checkpoint 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus PML Body	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Protein C-terminus Binding FHA Domain Binding
	Biological Process	DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Double-strand Break Repair Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Peptidyl-serine Phosphorylation Mitotic Intra-S DNA Damage Checkpoint Signaling Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Protein Catabolic Process Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Cellular Response To Xenobiotic Stimulus Cellular Response To Gamma Radiation Mitotic Spindle Assembly Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Response To Glycoside Cellular Response To Bisphenol A Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Anoikis	DNA Repair Mitotic Intra-S DNA Damage Checkpoint Signaling
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs		XL844 Enzastaurin Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Breast cancer ( 29059683 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Immature fraction of reticulocytes ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung cancer ( 24880342) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Menopause (age at onset) ( 26414677) Myeloproliferative neoplasms ( 33057200) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Optic disc size ( 31809533) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29117387) Red cell distribution width ( 32888494 28957414) Smoking initiation ( 33082346) Vertical cup-disc ratio ( 20548946 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)
Interacting Genes		85 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CRKL CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 FUS GNAS GRK3 HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MN1 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 POLR2L PPM1D PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP SUSD2 TLR3 TP53 TSSK1B USP39 VHL	41 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID		11200	9656
HPRD ID		05084	16252
Ensembl ID		ENSG00000183765	ENSG00000137337
Uniprot IDs		O96017	A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs		1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK	2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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