MDC1 and WRN

  • Number of citations of the paper that reports this interaction (PubMedID 14578343)
  • 91
  • Data Source:
  • BioGRID (unspecified method)

MDC1

WRN

Description mediator of DNA damage checkpoint 1 WRN RecQ like helicase
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronotype ( 30696823)
  • Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903)
  • Daytime sleep phenotypes ( 27126917)
  • Exercise treadmill test traits ( 17903301)
  • Fasting glucose change (long-term) ( 31263163)
  • Intelligence (MTAG) ( 29326435)
  • Lifespan ( 25918517)
  • Logical memory (delayed recall) in mild cognitive impairment ( 29274321)
  • Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
  • Metabolite levels ( 23823483)
  • Morning person ( 30696823)
Interacting Genes 41 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251 37 interacting genes: ADRB3 ATM ATRX BARD1 BLM BRCA1 C8orf86 CDKN2A FEN1 H2AX HTR5A MDC1 MDM2 MIB1 PARP1 PCNA POLB POLD2 POLK POLR1C PRKAR1B PRKDC RAD1 RAD51 RAD52 RAD54B RAD9A RPA1 SUMO1 SUMO2 TERF2 TP53 UBXN8 VCP WRNIP1 XRCC5 XRCC6
Entrez ID 9656 7486
HPRD ID 16252 05212
Ensembl ID ENSG00000137337 ENSG00000165392
Uniprot IDs A0A1U9XBC1 A1Z5I9 Q14676 Q14191
PDB IDs 2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT 2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF 6TYV 6YHR
Enriched GO Terms of Interacting Partners?
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