MDC1 and CENPC

Number of citations of the paper that reports this interaction (PubMedID 14578343)
91

Data Source:
BioGRID (unspecified method)

		MDC1	CENPC
Description		mediator of DNA damage checkpoint 1	centromere protein C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body	Kinetochore Condensed Chromosome, Centromeric Region Nucleoplasm Pericentric Heterochromatin Cytosol Nuclear Body Midbody
	Molecular Function	Protein Binding Protein C-terminus Binding FHA Domain Binding	DNA Binding Protein Binding Centromeric DNA Binding Identical Protein Binding
	Biological Process	DNA Repair Mitotic Intra-S DNA Damage Checkpoint Signaling	Mitotic Cell Cycle Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Monopolar Spindle Attachment To Meiosis I Kinetochore
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Walking pace ( 33128006)
Interacting Genes		41 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251	7 interacting genes: DAXX ELOC MAPK14 MDC1 SUMO2 TRIM14 UBTF
Entrez ID		9656	1060
HPRD ID		16252	00315
Ensembl ID		ENSG00000137337	ENSG00000145241
Uniprot IDs		A0A1U9XBC1 A1Z5I9 Q14676	Q03188
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT	5LSJ 5LSK 6MUO 6MUP 6SE6 6SEE 6SEF
Enriched GO Terms of Interacting Partners?
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