MED12 and MED13

Number of citations of the paper that reports this interaction (PubMedID 15175163)
116

Data Source:
HPRD (in vitro, in vivo)

		MED12	MED13
Description		mediator complex subunit 12	mediator complex subunit 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane Mediator Complex	Nucleus Nucleoplasm Membrane Mediator Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Protein Domain Specific Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Transcription Coactivator Activity Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Endoderm Development Heart Development Oligodendrocyte Development Schwann Cell Development Protein Ubiquitination Stem Cell Population Maintenance Spinal Cord Development Post-anal Tail Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Axis Elongation Involved In Somitogenesis Embryonic Brain Development	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cholesterol Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Triglyceride Homeostasis
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome MED12-related disorders, including: Lujan-Fryns syndrome (LFS); Lujan syndrome; X-linked mental retardation with Marfanoid habitus; FG syndrome type 1 (FGS1); Opitz-Kaveggia syndrome
GWAS		Uterine fibroids ( 31649266)	Coffee consumption ( 31046077) Initial pursuit acceleration ( 29064472) Objective response to lithium treatment ( 26503763) PR segment ( 24850809)
Interacting Genes		16 interacting genes: CDK8 ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED29 MED8 MED9 NANOG PPARGC1A SOX9 SREBF1 VDR	8 interacting genes: ESR1 MED12 MED13L MED23 MED29 MED9 SREBF1 TSC22D2
Entrez ID		9968	9969
HPRD ID		02176	07229
Ensembl ID		ENSG00000184634	ENSG00000108510
Uniprot IDs		Q93074	A0A024QZ75 Q9UHV7
PDB IDs
Enriched GO Terms of Interacting Partners?
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