MED12 and NANOG

Number of citations of the paper that reports this interaction (PubMedID 19036726)
26

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MED12	NANOG
Description		mediator complex subunit 12	Nanog homeobox
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane Mediator Complex	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Protein Domain Specific Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Endoderm Development Heart Development Oligodendrocyte Development Schwann Cell Development Protein Ubiquitination Stem Cell Population Maintenance Spinal Cord Development Post-anal Tail Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Axis Elongation Involved In Somitogenesis Embryonic Brain Development	Endodermal Cell Fate Specification Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Stem Cell Proliferation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome MED12-related disorders, including: Lujan-Fryns syndrome (LFS); Lujan syndrome; X-linked mental retardation with Marfanoid habitus; FG syndrome type 1 (FGS1); Opitz-Kaveggia syndrome
GWAS		Uterine fibroids ( 31649266)
Interacting Genes		16 interacting genes: CDK8 ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED29 MED8 MED9 NANOG PPARGC1A SOX9 SREBF1 VDR	7 interacting genes: BRAF MED12 PRKCE RBPMS RHOXF2 SPOP USP21
Entrez ID		9968	79923
HPRD ID		02176	06397
Ensembl ID		ENSG00000184634	ENSG00000111704
Uniprot IDs		Q93074	A8K4D1 Q9H9S0
PDB IDs			2KT0 4RBO
Enriched GO Terms of Interacting Partners?
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