MED12 and MED8

Number of citations of the paper that reports this interaction (PubMedID 12584197)
20

Data Source:
HPRD (in vitro)

		MED12	MED8
Description		mediator complex subunit 12	mediator complex subunit 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane Mediator Complex	Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Protein Domain Specific Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding
	Biological Process	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Endoderm Development Heart Development Oligodendrocyte Development Schwann Cell Development Protein Ubiquitination Stem Cell Population Maintenance Spinal Cord Development Post-anal Tail Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Axis Elongation Involved In Somitogenesis Embryonic Brain Development	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome MED12-related disorders, including: Lujan-Fryns syndrome (LFS); Lujan syndrome; X-linked mental retardation with Marfanoid habitus; FG syndrome type 1 (FGS1); Opitz-Kaveggia syndrome
GWAS		Uterine fibroids ( 31649266)	Feeling worry ( 29500382) Schizophrenia ( 28991256)
Interacting Genes		16 interacting genes: CDK8 ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED29 MED8 MED9 NANOG PPARGC1A SOX9 SREBF1 VDR	31 interacting genes: APP ARRB2 CCNC CDK8 CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 SNTA1 THOC7 UBALD1 USP49
Entrez ID		9968	112950
HPRD ID		02176	06991
Ensembl ID		ENSG00000184634	ENSG00000159479
Uniprot IDs		Q93074	Q96G25
PDB IDs
Enriched GO Terms of Interacting Partners?
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