RIMS2 and CACNA1S

Number of citations of the paper that reports this interaction (PubMedID 14660679)
74

Data Source:
HPRD (in vitro)

		RIMS2	CACNA1S
Description		regulating synaptic membrane exocytosis 2	calcium voltage-gated channel subunit alpha1 S
Image
GO Annotations	Cellular Component	Cell Junction Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Presynaptic Active Zone Cytoplasmic Component	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex T-tubule I Band L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protein Binding Rab GTPase Binding Ion Channel Binding Metal Ion Binding	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium Ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Calcium Ion Transport Muscle Contraction Regulation Of Ion Transmembrane Transport Cardiac Conduction Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine
Pathways			NCAM1 interactions Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs			Isradipine Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Magnesium Sulfate Verapamil Ethanol Felodipine Nitrendipine Nifedipine Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Pinaverium Manidipine
Diseases			Hypokalemic periodic paralysis (HypoPP)
GWAS		Cocaine dependence ( 23958962) High density lipoprotein cholesterol levels ( 30498476) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple system atrophy (pathologically confirmed) ( 27629089)	Cardiac Troponin-T levels ( 31014085) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Inflammatory bowel disease ( 28067908) Permanent tooth development ( 21931568) Tooth agenesis ( 29364747) Ulcerative colitis ( 28067908 20228799) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		13 interacting genes: ABCA1 CACNA1S PABPC1 RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH	4 interacting genes: PDZD3 RIMS2 RYR1 SRI
Entrez ID		9699	779
HPRD ID		09436	00248
Ensembl ID		ENSG00000176406	ENSG00000081248
Uniprot IDs		Q9UQ26	B1ALM3 Q13698
PDB IDs		1V27 1WFG	2VAY 6B27
Enriched GO Terms of Interacting Partners?
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