RIMS2 and RPH3AL

Number of citations of the paper that reports this interaction (PubMedID 10707984)
74

Data Source:
HPRD (two hybrid, in vivo)

		RIMS2	RPH3AL
Description		regulating synaptic membrane exocytosis 2	rabphilin 3A like (without C2 domains)
Image			No pdb structure
GO Annotations	Cellular Component	Cell Junction Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Presynaptic Active Zone Cytoplasmic Component	Cytoplasm Transport Vesicle Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding Rab GTPase Binding Ion Channel Binding Metal Ion Binding	Protein Binding Cytoskeletal Protein Binding Rab GTPase Binding LIM Domain Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium Ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Intracellular Protein Transport Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Secretion Response To Drug Glucose Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Cocaine dependence ( 23958962) High density lipoprotein cholesterol levels ( 30498476) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple system atrophy (pathologically confirmed) ( 27629089)	AIDS progression ( 21502085) Dimensional psychopathology (Cognitive) ( 29496196) Idiopathic intracranial hypertension ( 29608535) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001)
Interacting Genes		13 interacting genes: ABCA1 CACNA1S PABPC1 RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH	13 interacting genes: MID2 RAB27A RAB27B RAB3A RAB3B RAB3C RAB3D RAB3GAP1 RAB8A RIMS2 TCEA3 UNC13B ZYX
Entrez ID		9699	9501
HPRD ID		09436	05345
Ensembl ID		ENSG00000176406	ENSG00000181031
Uniprot IDs		Q9UQ26	A8K7D5 Q9UNE2
PDB IDs		1V27 1WFG
Enriched GO Terms of Interacting Partners?
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