CACNA1S and PDZD3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CACNA1S	PDZD3
Description		calcium voltage-gated channel subunit alpha1 S	PDZ domain containing 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex T-tubule I Band L-type Voltage-gated Calcium Channel Complex	Cytosol Plasma Membrane Brush Border Apical Junction Complex Apical Part Of Cell
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Ubiquitin-specific Protease Binding
	Biological Process	Calcium Ion Transport Muscle Contraction Regulation Of Ion Transmembrane Transport Cardiac Conduction Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity
Pathways		NCAM1 interactions Phase 0 - rapid depolarisation Phase 2 - plateau phase	Intestinal infectious diseases
Drugs		Isradipine Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Magnesium Sulfate Verapamil Ethanol Felodipine Nitrendipine Nifedipine Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Pinaverium Manidipine
Diseases		Hypokalemic periodic paralysis (HypoPP)
GWAS		Cardiac Troponin-T levels ( 31014085) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Inflammatory bowel disease ( 28067908) Permanent tooth development ( 21931568) Tooth agenesis ( 29364747) Ulcerative colitis ( 28067908 20228799) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		4 interacting genes: PDZD3 RIMS2 RYR1 SRI	18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C NLRX1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7
Entrez ID		779	79849
HPRD ID		00248	06191
Ensembl ID		ENSG00000081248	ENSG00000172367
Uniprot IDs		B1ALM3 Q13698	B0YJ61 Q86UT5
PDB IDs		2VAY 6B27	2V90
Enriched GO Terms of Interacting Partners?
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