CACNA1S and RYR1

Number of citations of the paper that reports this interaction (PubMedID 9199552)
65

Data Source:
HPRD (in vivo)

		CACNA1S	RYR1
Description		calcium voltage-gated channel subunit alpha1 S	ryanodine receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex T-tubule I Band L-type Voltage-gated Calcium Channel Complex	Cell Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Z Disc Junctional Membrane Complex T-tubule Cytoplasmic Vesicle Membrane Integral Component Of Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding	Protease Binding Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity
	Biological Process	Calcium Ion Transport Muscle Contraction Regulation Of Ion Transmembrane Transport Cardiac Conduction Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Calcium Ion Cellular Response To Caffeine Regulation Of Cardiac Conduction
Pathways		NCAM1 interactions Phase 0 - rapid depolarisation Phase 2 - plateau phase	Stimuli-sensing channels Ion homeostasis
Drugs		Isradipine Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Magnesium Sulfate Verapamil Ethanol Felodipine Nitrendipine Nifedipine Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Pinaverium Manidipine	Caffeine Dantrolene Suramin Tetracaine
Diseases		Hypokalemic periodic paralysis (HypoPP)	Central core disease
GWAS		Cardiac Troponin-T levels ( 31014085) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Inflammatory bowel disease ( 28067908) Permanent tooth development ( 21931568) Tooth agenesis ( 29364747) Ulcerative colitis ( 28067908 20228799) Urinary albumin-to-creatinine ratio ( 31511532)	Abstraction and mental flexibility ( 31596458) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Diisocyanate-induced asthma ( 25918132) Peanut allergy (parent-of-origin effect) ( 29489655) White blood cell count (basophil) ( 27863252)
Interacting Genes		4 interacting genes: PDZD3 RIMS2 RYR1 SRI	16 interacting genes: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PRKACA PRKG1 RYR2 S100A1 TRDN
Entrez ID		779	6261
HPRD ID		00248	01618
Ensembl ID		ENSG00000081248	ENSG00000196218
Uniprot IDs		B1ALM3 Q13698	P21817
PDB IDs		2VAY 6B27
Enriched GO Terms of Interacting Partners?
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