RIMS2 and RAPGEF4

Number of citations of the paper that reports this interaction (PubMedID 11598134)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		RIMS2	RAPGEF4
Description		regulating synaptic membrane exocytosis 2	Rap guanine nucleotide exchange factor 4
Image			No pdb structure
GO Annotations	Cellular Component	Cell Junction Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Presynaptic Active Zone Cytoplasmic Component	Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	Protein Binding Rab GTPase Binding Ion Channel Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding CAMP Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium Ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Calcium Ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle
Pathways			Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Cocaine dependence ( 23958962) High density lipoprotein cholesterol levels ( 30498476) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple system atrophy (pathologically confirmed) ( 27629089)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)
Interacting Genes		13 interacting genes: ABCA1 CACNA1S PABPC1 RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH	12 interacting genes: ATXN1 BMERB1 LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A
Entrez ID		9699	11069
HPRD ID		09436	06929
Ensembl ID		ENSG00000176406	ENSG00000091428
Uniprot IDs		Q9UQ26	B7Z278 Q8WZA2 X5D7N4
PDB IDs		1V27 1WFG
Enriched GO Terms of Interacting Partners?
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